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Jumat, 30 April 2010

Keys To Happiness

n this era of science and technology, we can be creative and productive, and at the same time not lose the humanness that we are born with. Just material things or comforts alone do not make you comfortable. You may have a good bed to sleep on, but unable to sleep because of insomnia or worry. Here are a few key points on how you can improve the standard of your life and thus live a better happy life.

'? Stay healthy:

Health is...

A disease-free body

A quiver free breath.

A stress free mind.

An inhibition- free intellect.

An obsession free memory.

An ego that includes all.

A soul that is free from sorrow.

'? Review the content of your life

Look at your life in the light of time. Millions of years have passed and millions will come. What is your life? 60 or 70 years? Span of life is insignificant. In terms of space, you simply don't exist. This understanding dissolves your ego. Ego is ignorance of your reality. So, the key to happiness is 'dissolve your egos'

'? Know life's impermanence

See the impermanence in this life. That is the truth. Turn back and see that all that you did is just like a dream. You don't have to be afraid of life. There is always support. This hope is the key to happiness.

'? Make your smile cheaper

A research done in England found that a baby smiles 400 times a day, an adolescent'''''''''''''' 17 times and an adult doesn't smile at all!! Is roughness a sign of success Is being stressed a sign of prosperity, growth or dignity? You should smile more... everyday, every morning, look at the mirror and give a good smile at yourself. You know what happens when you smile? All the muscles in your face get relaxed. The nerves in your brain get relaxation and you get the confidence, courage and energy to move on in your life. Take a challenge:' come what may, I am going to smile and be happy'

'? Be enthusiastic and praise others:

Enthusiasm is the nature of life. We often have a tendancy to put cold water on other's enthusiasm. Reverse this tendancy. Take every opportunity to praise others and support their enthusiasm.

With these keys happiness is all yours...



Source : Readbud Read more...

Chlamydia: Facts About Chlamydia Infection

Chlamydia is one of the most common sexually transmitted disease, especially among teens. It is anticipated that three million people are infected with Chlamydia annually in the United States, which is prevalent in both men and women. The major problem with this infection is that there usually aren't any symptoms because most women don't know they have the infection. When symptoms occur, they may be mild and may disappear within a few days. Noticeable symptoms may not occur unless the infection is severe; symptoms that you could have are: vaginal discharge, spotting or irregular periods, lower abdominal pain, and burning with urination.

The infection can be transferred to partners during oral, anal or genital sex. The organism can be carried by hand to your eyes and it can also be passed to a newborn during birth if the mother is infected. Complications occur often because people do not know they have Chlamydia, so it goes untreated in the early stages. The complications in women include: Pelvic Inflammatory Disease (PID). Chlamydia usually infects the vagina and cervix, but the infection can ascend and involve the uterus and fallopian tubes; An increased risk of getting HIV; Blindness caused by Trachoma which is a severe eye infection coming from Chlamydia getting into the eye; Lymphogranuloma venerum that causes open sores in the genital area and swollen lymph nodes; and Reiter's syndrome which is a form of arthritis. Infants who are delivered vaginally by mothers with active Chlamydia infection are at risk for acquiring an eye infection and pneumonia.

The infection is diagnosed with a pelvic exam and vaginal swab to check for the organism. If you have any symptoms of the disease, your health practitioner will test for it. The CDC suggest annual Chlamydia screening test, with a pelvic exam and vaginal swab, for all sexually active women under the age of 25 and for women over the age of 25 who have new or multiple sexual partners. Chlamydia can be treated with antibiotics so if you have, it is important to take the necessary antibiotics prescribed and to complete any follow-up tests your health practitioner recommends. It is also imperative that all of your sexual partners will be treated; if only one partner is treated, you can re-infect each other.

Since it is transmitted sexually, obviously abstinence or having sex only within a mutually monogamous relationship with an uninfected partner will prevent infection from occurring. If you have new or multiple sexual partners, condoms can provide some, but not complete protection against Chlamydial infections. You can transfer Chlamydia without vaginal penetration, though, so the condom or some other barrier should be worn with any genital-genital, genital-anal or genital-oral contact.

Chlamydia is a grave health threat since it is becoming so widespread and it can cause serious complications. Most people have even no idea if they are infected; and the disease is reaching epidemic magnitude particularly among teens. Safe sex practices are the key to prevention; early detection and treatment through routine screening of people who are at risk can we avoid complications.


Source : Readbud
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How To Feed Baby

Before the birth of the first child the mother is prepared with a list of printed materials and accessories in the road that supplies the hospital or clinic. One of the first objects that the baby will be born and no more contact with diapers and bottles, is the pacifier. But what is the exact role of pacifier and why now there is great diversity of pacifiers and how and why we use a pacifier.

Raising baby rabbits are not just like taking care of kittens or puppies because their mothers have a different way of nursing their young. Mother rabbits are very central to the lives of their babies or kits because they don't stop taking care of them until they are strong enough to fend for themselves. Thus, in raising baby rabbits, one must also give equal care to the doe in order to properly support the young. The first thing that needs to be done in raising baby rabbits is setting up a comfortable nest for the doe days before it is about to give birth.

Combination Feeding. It is important that from birth breast-fed babies learn to drink from a bottle. The baby can be offered plain, boiled water from a small bottle to pacify him or her between nursing times. A baby of three or four months who has never had a bottle will obstinately refuse one when the mother decides to wean. Such a baby's stubborn resistance, countering the mother's insistence, can make for a frustrating time.

Baby rabbit care is basically a simple task because the mothers of these animals originally take over with regards to the actual nursing. The only preparation that a rabbit owner needs to take care of comes with the preparation of the litter, the nest, and keeping the temperature suitable for the baby. There is not much problem with food though most owners think that mother rabbits don't feed their young because they don't see them nursing the infants after birth. The reality, however, is that the mothers only feed the babies once a day and between 12 midnight to 5 am so most owners just don't see the deed done.

Introducing solid foods should be done with caution and care. Your baby is now getting more nutrition and vitamins than milk or formula has to offer. They are also trying new flavors and textures some of which they will like and some they will spit out. As a parent, you also have to be aware of food allergies. It's really important to record any foods that your baby doesn't like or experiences food allergies with.

At present the World Health Organisation recommends that all babies be breastfed exclusively for six months. A long time, you may think, especially in the middle of a colic episode or growth spurt! However, there are real concerns for the welfare of babies that have led to this advice.

In the past many babies were fed solid foods at very young ages. It is now believed that their bodies were unable to cope with the demands this placed on them; a dramatic increase in the incidence of allergies and food intolerances meant guidelines were reviewed and altered.



Source : Readbud
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Make Your Home A Home On The Range For Your Little Cowpoke

Turn his new bedroom into a well-appointed dude ranch accommodation and your baby buckaroo is sure to sleep soundly, surrounded by accessories in authentic-looking imitation cowhide and by the variety of exciting western images on his cowboy baby bedding. After a while, you'll be able to regale him with tales of the heroes of the Old West, and - like his daddy before him - he will dream of putting on his boots, donning his ten-gallon hat, vaulting into the saddle, and riding off into the sunset after a pack of low-down cattle rustlers.

All sorts of merchandise is available online for those who want to prepare a nursery using this extremely popular, iconic theme. Even the most basic of internet searches will turn up pages and pages of retailers who stock cowboy bedding options. Cowboys, horses and prairie vegetation will appear in profusion in a wide assortment of styles, with tans, browns, reds, and greens predominating.

In these trying economic times, however, many parents find it difficult to contemplate the expenses they imagine they will face if they undertake such a decorating project. They will undoubtedly be pleased to discover that spending a little extra time and putting forth a little extra effort will enable them to purchase whatever they desire in the way of baby boy bedding. Resourceful moms and dads are freeing up money for beautiful bed linens and window treatments by finding ways to save on the much larger expense of nursery furniture.

They are building their own cribs and changing tables or assembling them from low-priced kits, refinishing ones used by friends or relatives whose kids have outgrown them, or even browsing through Free cycle and Craigslist for free or extremely inexpensive items of more than acceptable quality.

Once that is accomplished, they won't have to do any skimping when it comes to buying nursery accessories and crib bedding. For under $200, they can usually get an entire roomful of highly desirable items which have been coordinated in advance and packaged together to make a complete decorating set.

Of course, even red-blooded little future cowboys need to be protected by the grown-ups who are shopping for their crib gear. Quilts and sheets must be of the proper density and dimensions, so as not to risk cutting off their air supply, and they must be free of any chemicals which could prove dangerous to immune systems or respiratory function. Then, keeping those key requirements in mind, expectant parents can embark confidently on the delightful task of setting up a bunkhouse worthy of their newborn son.

Time passes away, but parents have not yet made up their minds about the crib bedding. How is this possible? Choosing baby bedding should be easy, not stressful. Many parents depend on the baby shower to provide them with sufficient baby bedding. The shower arrives and as expected there is sufficient baby bedding - but now there is a new problem.

After you choose proper bedding, you will wonder how much time and money you have saved. Sometimes termed "nursery in a bag", a collection that incorporates in it matching accessories would undoubtedly take you to a fully decorated room just one hour after the box is delivered at your doorstep - providing you with the liberty to enjoy when you think about your sweet daughter who would soon go into sleep calmly in her pink and brown nursery.

Baby bedding that you buy within a bigger ensemble will ensure that you're not anxious about how you're going to decorate your baby girl's nursery. Most baby bedding sets combine sheets, blankets, and bumper protectors which follow conventional standards for safety. This bedding conforms to conventional measurements for cribs and tot beds and most often are free of allergens and toxins so that your sweet infant will have a safe start.


Source : Readbud
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A Short Discussion On Colored Contact Lenses

Contact lens is one of the latest trends of fashion nowadays; it is used by people at a large extent. The colored contact lenses are used by teenagers and even middle aged people extensively. This trend of wearing colored contact lens was started by the celebrities like all other fashion materials. Later this trend became prevalent among the general people. Contact lens for fashion purpose is mainly used to enhance or change the color of the eyes. Many people who want to adore their eyes use colored contact lens. And with the increase in competition in the contact lens market, the price of the lenses has decreased largely. The colored contact lenses make one's eyes more interesting and gorgeous.

Contact lenses of various types are available in plenty in the market and in the online stores. Few types of lenses which are used by the common people and are available in plenty in the market are, the opaque contact lens, colored lens having the enhancement tint, lenses having just the visibility tints etc. Now let us discuss in brief about these above mentioned contact lenses. The opaque contact lens, as the name resembles is completely opaque and are used to change the eye color completely. If a person wants to change the color of his or her eyes from say black to blue, then the opaque colored lenses are the best option. These lenses are used at large extent among the general people. These lenses are made using a unique technique; the middle part of the lens is kept blank so that a person does not face difficulty while seeing. The rest area is colored deeply, so that it changes the eye color when it is set on the iris part. The next one, the lenses which have enhancement tint is generally used to enhance the color of the eyes. These contact lenses are transparent and do not change the eye color completely. People use these lenses to give their eyes a sparkling look so that they look more interesting. The next in queue are the lenses having visibility tints; these lenses are provided with just a little blue or green tint so that the user does not lose the lens while cleaning or when soaking in the solution.

The use of colored contact lenses has spread extensively in the past few years; millions of people use colored lenses either for changing their eye color, enhancing the original color of their eyes and even for their convenience. Contact lenses are available in plenty in the market and you can use any lens you feel suitable for your eyes. But, consulting an eye specialist before taking a lens is very important as the contact lens you are going to use may not suite your eyes, and it may also cause severe infections and other problems to your eyes. After purchasing a contact lens, you should take good care of it. The solution that is provided with the contact lens is very important to keep the lens good and last long. Well maintained contain contact lenses do not cause any irritation or problems to the eyes.



Source : Readbud Read more...

Are You Looking For A Weght Loss Boot Camp?

Many people have heard about weight loss boot camps, either from friends or in various health magazines and TV shows. There are specific reasons why they are an excellent and proven way for many people to get rid of a lot of weight quickly.

If you have tried every diet under the moon, stars and sun and have been trying for quite a while, you probably know it isn't an easy task. You may even know of several people who can lose weight at the drop of a hat.

Unfortunately, we are not all the same. When all other previous attempts have failed, you might have looked at, liposuction or prescribe diet pill or some other expensive way to help you loss weight.

The amazing thing about weight loss and dieting is that most people don't really understand what's really involved. You maybe one of those people who think that all you have to do is eat less food, take a dietary aid or supplement like Wu-yi tea or the Acai berry and get some of exercise like aerobics and the excess fat will just fall off.

By now, you have probably learnt that's not enough. Is it time to get some expert help from people who know all the ins and outs of weight reduction? Weight loss boot camps can provide that guidance.

So! What are these weight loss camps all about?

Did you know that, a good weight loss camp will deal with more than your weight? Good programs design a personalised program specifically for your situation. If you think that means having to eat bland, tasteless foods that leave you always feeling hungry, you're completely wrong. You will be put on a great, nutritious health diet that is purposely designed to help you get rid of that weight as safely and quickly as possible.

Many weight loss camps for adults will sometimes use a holistic a approach to getting you slim, which means they'll help you to sort out any personal problems you might have that inhibited you from getting rid of some excess fat in the past. Emotionally consuming food is very common. People with this disorder generally to turn to food whenever they get very upset or stressed.

If you are one of these people, then you can expect a good slimming boot loss camp to help you sort this problem out.

However there are some things you should have in mind when searching for a quality weight loss camp for men and women.

A good weight loss camp will provide you with a well structured regime that addresses your needs for a healthy lifestyle.

Is the camp more concerned about your money or is it more concerned about getting you ready for a future healthy lifestyle?

Are the facilities at the camp geared towards helping you to achieve long-term weight loss results?

What kind of experienced and trained personal do they have employed at the camp: physical fitness experts, dieticians and nutritionists? And are they certified in their area of expertise?.

Is there individual and persona assistance at the camp or is it targeted towards group sessions only?

How many people will be in attendance in each session? If the groups are too numerous, it is possible that you may not get the assistance you require.

Is there any kind of support or after care once you have completed your term? This is important. You may want to speak to someone if you start to slip or have any or questions about your health or weight once you have left.

It is a good idea to check these points to be sure that the weight loss boot camp you are interested in attending can give you the desired results you want.



Source : Readbud

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Kamis, 29 April 2010

DNA egg swap prevents rare diseases

London - British scientists have mastered a controversial technique using cloning technology to prevent some incurable inherited diseases by swapping DNA between two fertilised human eggs.

Lead researcher Doug Turnbull of Newcastle University said on Wednesday he hoped the first babies free from so-called mitochondrial diseases would be born within three years.

But applying the technique in the clinic, to help women at risk of passing on the disorders, will require a change in British law that currently bans reproduction from such manipulated embryos, which would end up having three biological parents.

Around one in 6 500 children are born with serious diseases caused by malfunctioning mitochondrial DNA, leading to a range of conditions that can include fatal heart problems, liver failure, brain disorders, blindness and muscular weakness.

The Newcastle team's technique effectively replaces mitochondria, which act as tiny energy-generating batteries inside cells, so a baby doesn't inherit faults from its mother. Mitochondria are only passed down the maternal line.

"What we've done is like changing the battery on a laptop. The energy supply now works properly, but none of the information on the hard drive has been changed," Turnbull said.

"A child born using this method would have correctly functioning mitochondria, but in every other respect would get all their genetic information from their father and mother."

The researchers use a variation of the same technique used to make Dolly the cloned sheep in 1996.

Within a day of uniting egg and sperm using in vitro fertilisation, nuclear DNA is removed from the embryo and implanted into a donor egg, whose own nucleus has been removed and discarded.

The resulting embryo inherits nuclear DNA, or genes, from both its parents but mitochondrial DNA from a second "mother" who donated the healthy egg. In humans, about 37 genes are found in the mitochondria - the rest of the more than 20 000 known genes are in the DNA found in the nucleus.

For critics like Josephine Quintavalle of campaign group Comment on Reproductive Ethics that makes it "a step too far in meddling with the building blocks of human life".

"No matter how small the contribution from the egg of the donor woman, the fact remains that an attempt is being made to create a three-parent child," she said.

But Alison Murdoch of the Newcastle Fertility Centre, whose patients donated eggs used in the studies, told reporters such criticisms ignored the fact that all the characteristics of the baby would come from its two real parents.

Researchers in Newcastle first disclosed two years ago they had created a handful of embryos with swapped DNA, but it is only now that the process has been shown to produce viable embryos.

Writing in the journal Nature, the team said 80 embryos were created and developed in the laboratory for six to eight days to reach the blastocyst stage, comprising a ball of around 100 cells. They were then destroyed, in line with current rules. - Reuters


Source : Babynet Read more...

Women who take the Pill live longer - study

Paris - A 39-year study of women taking the contraceptive pill found that they had a have a lower risk of dying from any cause compared with women who had never taken it, researchers said.

"Oral contraception was not associated with an increased long term risk of death in the large UK cohort, indeed a net benefit was apparent," said the study published in the British Medical Journal.

Over 46 000 women were observed during the Royal College of General Practitioners' Oral Contraception Study which was carried out by researchers at Aberdeen University in Scotland.

The researchers added that the results would reassure women who took the "first generation" of oral contraceptives.

However they said the findings "might not reflect the experience of women using oral contraceptives today" due to possible differences in the more modern versions of the drug. - Sapa-AFP


Source : Babynet Read more...

Ready or not, your eggs are almost done

Whether you are aware of your incessantly ticking biological clock or not, the absolute last thing that any woman of steadily advancing childbearing age wants to hear when she flips on the morning news shows is: women lose 90 percent of their eggs by age 30.

Thirty? Life has hardly begun at 30! Gulp.

The hard truth is that decades of research have proved that a woman's fertility declines over time. But now it appears that the old biological clock may start ticking much earlier - and faster - than once thought.

A study from the University of St Andrews and Edinburgh University, published last month by PLoS ONE, tracked the human ovarian reserve - or a woman's potential number of eggs - from conception through menopause.

Using a mathematical model and data from 325 women, the researchers found that the average woman is born with about 300 000 eggs and steadily loses them as she ages, with just 12 percent of those eggs remaining at the age of 30, and only three percent left by 40.

"That's a greater percentage of loss at an earlier age than had previously been reported," says reproductive endocrinologist Robert Stillman of Maryland.

"One might be able to argue whether there are 12 percent remaining at age 30 or 22 percent or even 40 percent, but it is still clear that there's a very rapid loss in the number of eggs available as women age and that the smaller pool of (older) eggs is also more likely to contain a higher proportion of abnormal eggs, he adds, pointing out that from the mid-30s on, the decline in fertility is much steeper with each passing year.

"This adds to the abundant evidence that for women, unfortunately, it's use 'em or lose 'em."

Before you start freaking out, it's important to remember that even 30 000 or so eggs remaining at the start of your 30s is still a lot. In addition, the quantity and quality of eggs are just two factors affecting fertility.

Plenty of women get pregnant perfectly easily in their 30s and even early 40s.

Also, infertility technology has come a long way in even the past decade. Still, given that a study published last year in the journal Fertility and Sterility found that female undergraduates significantly overestimated their fertility prospects at all ages, it seems wise for women thinking about starting a family - or having more children - to educate themselves about ageing's effects on conception and pregnancy.

Important

"Don't leave (having a child) too late, if it is something that is going to be very important to you," says W Hamish Wallace, a co-author of the Fertility and Sterility study.

He says he hopes this research will help doctors advise young cancer patients on how best to preserve their fertility after treatment and improve counselling for healthy women.

The biological reality that female fertility peaks in the teens and early 20s can be difficult for many American women to swallow, as they delay childbirth further every year, according to the National Centre for Health Statistics.

In the District of Columbia, the average age of initial childbirth was 26,5 years in 2006, up 5,5 years since 1970.

"While we may not be mature enough to conceive at a young age, nor should we, that is still when the body is most adept at conception and carrying a baby," says Claire Whelan, programme director of the American Fertility Association.

Stillman agrees, pointing out that research about advanced maternal age and motherhood today is clear: the older you get, the more difficult it is to get pregnant and the higher the chance of miscarriage, pregnancy problems such as gestational diabetes and hypertension, and chromosomal abnormalities such as Down syndrome.

A study published this month in Autism Research found that the risk of autism increases with a mother's age: women over 40 were 77 percent more likely than those under 25 to have a child with the condition.

There was also an elevated risk when the dad was over 40 and the mother was in her 20s.

"Society has changed," says Stillman, "but the ovaries will take another million years or two to catch up to that."

Since we don't have another million years to wait, many women thinking of having children are left with the predicament of balancing the personal, primal urge to partner up and procreate with worthwhile social goals such as pursuing higher education and a successful career - not to mention economic stability.

I remember that when my husband and I were deciding whether to try for our first baby in our late 20s.

We kept coming up with perfectly valid reasons to wait - needing to get health insurance; putting away some savings; travelling to one last far-flung locale; enjoying being alone together - and it never really occurred to me that there were also perfectly valid reasons to forge ahead in a timely fashion.

It doesn't make it any easier that the media are filled with mixed messages on women's fertility: compare the studies filled with doom-and-gloom statistics on advanced maternal age and pregnancy with the myriad photos of 40- or 50-something celebrities in magazines, holding their bouncing baby, projecting the image that fertility isn't as finite as it seems.

There are at least a few things worth noting in the meantime.

While the PLoS ONE study on ovarian reserve found that age alone affected a woman's store of eggs up until 25, lifestyle factors such as stress, smoking and being overweight can have an increasingly negative impact on fertility as you get older, say the authors and Whelan.

"You can't prolong your biological clock - you're not going to produce more eggs - but that's not the only factor around fertility," Whelan says.

"Women do need to start thinking proactively about their own reproductive health, and protecting it, as time passes." - Washington Post




  • This article was originally published on page 9 of The Daily News on March 02, 2010


Source : Babynet Read more...

Putting test tube babies to the test

Boys born as a result of IVF could inherit their father's infertility, scientists have warned.

A study has found that boys conceived using the popular form of fertility treatment often had shorter fingers - a trait associated with infertility.

It means techniques used to combat problems conceiving could be storing up problems for the future.

However, the boys in the study are too young for it to be known whether they are infertile.

Almost one in 50 babies born in Britain is conceived artificially.

Nearly half of these use a treatment called ICSI - intracytoplasmic sperm injection - in which an individual sperm is injected directly into the female egg.

It means it bypasses the normal "survival of the fittest" competition which sees only the healthiest sperm make its way to the egg, break through and fertilise it. The study, which was carried out at the Institute of Child Health in London, compared 211 six-year-olds conceived through ICSI with 195 naturally conceived children of the same age.

Although those in the ICSI group were of a similar height to the naturally conceived group, the boys had significantly shorter fingers, according to the journal Reproductive Biomedicine Online.

Men with low sperm counts often have ring fingers the same length as their index finger - while fertile men are more likely to have a ring finger that is longer.

Finger length is set within the first 14 weeks of pregnancy and is linked to testosterone exposure which is, in turn, governed by a specific set of genes.

Dr Alastair Sutcliffe, a paediatrician at the institute, said: "This is the first study of its kind. We don't yet know the implication of the findings because the children are very young, but we need to inform people."

The first ICSI baby was born in 1992 and there are around 3 700 such births a year in Britain.

John Manning, an evolutionary biologist at Southampton Univertechniquessity and one of the authors of the study, said: "This is telling us that we should only use ICSI when it is absolutely necessary.

"We know the extraordinary depression and pain that childlessness can cause and we have a responsibility to ensure that the focus on the well-being of the children born as a result of these methods is as high as it can be."

Josephine Quintavalle, from Comment on Reproductive Ethics, said ICSI was becoming the preferred option in infertility treatment because of a shortage of healthy sperm, caused by legislation requiring donors to agree to be identified to offspring in adulthood.

She said: "Using ICSI is obviously counter-intuitive to good health and this research would demonstrate that may be true."

A spokesperson for the Human Fertilisation and Embryology Authority, the watchdog which regulates private IVF clinics, said doctors should warn couples of the risks of treatment before they were enrolled as patients. - Daily Mail



  • This article was originally published on page 14 of The Cape Argus on February 10, 2010


Source : Babynet Read more...

Is it worth losing your left testicle?

ime of insemination determined a child's sex, while other ancient Greek philosophers thought it had something to do with the left and right sides of the body.

Two millennia later, an 18th-century French surgeon - writing under the pseudonym of Procope Couteau - took up the idea and advised men who wish to have baby boys to cut off their left testicle.

In more recent times, prospective parents who wish for either a boy or a girl have been offered all manner of remedies and food supplements to affect a baby's sex. But none of these folk recipes have been able to alter the fundamental biology that determines the 50:50 sex ratio.

A study published last week reveals a new twist to an ancient story. Scientists have found the probability of giving birth to a girl rather than a boy increases significantly the nearer the mother lives to the equator.

Conversely, the higher the latitude - and the further away from the equator - the greater the chances of a woman having a baby boy.

Kristen Navara of the University of Georgia in Athens studied the sex ratio of newborn boys to girls in 202 countries - from northern Europe to equatorial Africa - and found a clear link between latitude and a skewed sex ratio. The nearer to the equator, the greater the probability of baby girls, says the study.

The natural sex ratio at birth is slightly biased towards males in humans, with about 106 boys born to every 100 girls.

This sex ratio of 51.5 percent in favour of boys is believed to be nature's way of balancing the slightly increased risk of premature death in young males and so bringing the overall sex ratio in the child-rearing age groups nearer to the natural balance of 50:50.

But Navara found this average sex ratio at birth masks an underlying geographical trend. Using data on global birth rates compiled by the US's Central Intelligence Agency, Navara found countries in tropical latitudes produced fewer boys - 51.1 percent males - compared to countries in temperate and subarctic regions, where the sex ratio is 51.3 percent in favour of boys.

The difference may seem small, but it is nevertheless statistically significant, Navara said. It was even larger between some of the countries in the study. For instance, in tropical Central African Republic the sex ratio was 49 percent boys, whereas in more temperate China it was 53 percent in favour of boys, she said.

Sex in mammals is determined by the type of sperm that fertilises the egg. A sperm carrying the man's X chromosome will become a female embryo, whereas a sperm carrying the Y chromosome will produce a female embryo at conception. In theory, men produce equal numbers of X and Y sperms, which means the sex ratio at birth should be 50:50.

An exceptions to this rule is if male embryos and newborn boys are more likely to die prematurely. Another could come about if food is at risk of being in short supply. Now an underlying biological trend might be showing itself up more clearly in the latest study on latitude.

Navara said the difference in the birth sex ratio between higher and lower latitudes might reflect an ancient evolutionary mechanism caused by food resources in more northerly regions being more varied than in the tropics. - Foreign Service





Source : Babynet Read more...

Single embryo implants work better - study

Paris - Implanting single embryos into the wombs of women seeking to boost fertility is more effective and less costly than placing two embryos at a time, a pair of studies released Wednesday found.

The research contradicts the widely-held view that implanting multiple embryos during in-vitro fertilisation (IVF) is more cost-effective, and improves a woman's chances of becoming pregnant.

"At a time when there is an intense debate in many countries about how to reduce multiple pregnancy rates and provide affordable fertility treatment, policy makers should be made aware of our results," said the study's lead researcher Hannu Martikainen of the University of Oulu in Finland.

"These data should also encourage clinics to evaluate their embryo transfer policy and adopt elective single embryo transfer as their everyday practice for women younger than 40," she said in a statement.

The issue grabbed headlines earlier this year when a 33-year-old woman in California who underwent IVF gave birth to octuplets.

All of the infants survived, but multiple pregnancies are notoriously linked to premature births, low birthweight and neurological damage.

Some medical associations and governments have moved to tighten guidelines or regulations restricting the number of embryos that can be implanted during in-vitro fertilisation (IVF).

In Britain the Human Fertilisation and Embryology Authority (HFEA) controls IVF practices, limiting implanted embryos to two at a time. Just a single embryo will be allowed from 2011.

There are no national regulations in the United States. Professional guidelines suggest that a women under 35 should have no more than two implanted embryos. This can be increased to three from 35 to 37 years, to four embryos for ages 37-40, and five for a woman aged over 40.

In the new study, Martikainen and colleagues compared the outcomes of more than 3,600 assisted reproduction cycles at a major Finnish clinic across two time periods, 1995 to 1999, and 2000-2004. More than 1,500 women under 40 were treated.

During the first period, double embryo transfer was the norm, with single embryos being implanted in only four percent of women. During the second period, that percentage went up to 46.

The study, published by the reproductive medicine journal Human Reproduction, found that the live birth rate was five percent higher for women who had only one embryo implanted at a time.

The single embryo procedure was also cheaper, especially when health complications due to multiple births were taken into account.

"We found that a baby born alive at term using single embryo transfer was, on average, €19 899 (about R250 000) less expensive than babies born as a result of double embryo transfer," Martikainen said.

A second study, also in Human Reproduction, used a mathematical model to compare the cost effectiveness of three triple-cycle strategies: single embryo transfer for all patients, double embryo transfer only, or a choice between the two tailored to likelihood of pregnancy.

"The choice of which policy to implement depends on society's willingness to pay," said lead researcher Audrey Fiddelers at the Academic Hospital Maastricht in The Netherlands.

A strategy of implanting two embryos every time would result in more live births. But many of them would be multiple, and the average cost per child would be more than twice that of a single-embryo approach, the study concludes.



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Multiple births on the rise

As more women put off having babies until they are older and resort to fertility treatment to fall pregnant the number of multiple births is on the rise.

Families having to cope with triplets and quadruplets have often made for interesting media stories, but these days multiple births are becoming so regular that they no longer hold the same fascination.

There are the extreme cases, however, like that of Californian mother Nadya Suleman who recently had eight babies through in vitro fertilisation.

'In 2000 we had seven sets of twins - now we have 13'
At 33, single and unemployed with six children already, Suleman gave birth to her octuplets in January, sparking an international debate on the subject. Suleman and her doctor Michael Kamrava have again turned the spotlight on fertility treatments and multiple births.

Closer to home, families are having to cope with twins, triplets and other multiple birth children more frequently.

Heather Stevens, head of department at Parkside Primary in Queensburgh, said in her 17 years of teaching she had seen a dramatic increase in the number of multiples that had entered the school.

"In 2000 we had seven sets of twins and now, nine years later, we have 13."

Kim Monaghan, deputy principal of the foundation phase at Crawford North Coast Preparatory, which had eight sets of twins, said the number of multiples they have had in 2009 had been surprisingly high as well.

'No more than two embryos should be transferred for a woman under 35'
Pam Rowe, maternity unit manager at Life Westville Hospital, confirmed that there had definitely been an increase in the number of multiple births they had seen in the past few years, attributing the rise to the increased usage of fertility treatments.

Paediatrician Dr Andre Botha was frank.

"Looked at in perspective the general birth rates have remained stable. It is only within, and due to, the fertility industry that multiple births are on the uptake," he says.

"We in the neonatal sector are not too enthusiastic about fertility. If proper patient screening and low rather than high embryo implants occur, then there should not be multiple births," he said, maintaining that a successful fertility treatment should lead to a single baby, not twins, triplets or other multiples.

According to the American Society of Reproductive Medicine, no more than two embryos should be transferred for a woman under 35.

Strict limitations on the number of embryos transferred, as required by law in some countries, do not allow treatment plans to be individualised after careful consideration of each patient's own unique circumstances. Such restrictions, however, do not exist in South Africa.

Dr Sagie Naidu, reproductive specialist at the Durban Fertility Clinic, said it was incumbent on the fertility specialist to be responsible when counselling couples undergoing IVF treatments.

"There has definitely been a steady increase in the number of multiple births worldwide at about three pewrcent a year since 1990.

"In the last decade the increase was about 40 percent and since 1980 it has increased by 70 percent.

"Among the reasons for this increase is the age at which women give birth (women in their 30s are more likely to have a multiple pregnancy).

"It is thought to be due to higher levels of the follicle stimulating hormone and the widespread use of fertility treatments, including drugs to stimulate ovulation and assist reproductive methods such as artificial insemination and in vitro fertilisation," said Naidu.

Naidu said at the clinic they found that infertility treatments were becoming more widespread.

"This is due mainly to lifestyle changes. Women defer marriage and childbearing to focus on their careers. Stress and poor diets lead to conditions like polycystic ovaries (leading to difficulties with ovulation) and endometriosis.

"There is an increase in pelvic infection due to risky sexual behaviour causing blockage of fallopian tubes.

"Pollutants, alcohol and smoking also play a role in reducing sperm and egg quality.

"This is balanced by the fact that technology and skill in the area of infertility by reproductive specialists has substantially increased pregnancy rates.

"Couples therefore become complacent and delay starting their families, believing that fertility clinics will provide a solution if they don't conceive naturally later on."

Naidu said the rising number of multiple births posed a public health concern due to the increased risk of prematurity, low birth weights, increased risk of long term morbidity and early death.

"It is a concern for health authorities globally", he said.

"This is due to the high risk of prematurity growth impairment leading to low-weight birth babies.

"There is an increased risk of miscarriage, medical disorders like hypertension and anaemia and delivery by Caesarean section."

Physiotherapist Michelle Green said among the negative physical aspects of multiple birthing were the possibilities of increased tearing, haemorrhoids and a longer duration for the muscles to be strengthened.

A recent report illustrated the medical, financial and emotional risks of multiple births:

"A US study of nearly 250 mothers found that for each additional multiple birth child - from twins to triplets, for example, or triplets to quadruplets - the odds of having trouble meeting basic material needs more than tripled.

"The odds of lower quality of life and increased social stigma more than doubled with each added child. And the risk of depression in the mothers also rose with each additional child."

The experts we spoke to agreed that there are many complexities when it comes to birthing and raising twins or triplets, from the dangers in delivery, to them competing for your attention on a daily basis.

Overall it would appear that couples today underestimate the risks of multiple births and the enormity of providing care for multiple birth children.

  • This article was originally published on page 15 of The Mercury on February 26, 2009


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Why health at conception must be immaculate

London - The lives of future generations are being threatened because women trying for a baby are neglecting their health at the crucial moment of conception, doctors have warned.

The environment in which a foetus is conceived can be critical to the later physical and mental development of the child, affecting its IQ, its risk of obesity and of a range of diseases throughout life.

Advice about nutrition and lifestyle is widely followed in pregnancy, but few women pay attention to the recommendations when they are attempting to get pregnant.

More than three-quarters had planned their pregnancy
A study of more than 12 000 women aged 20 to 34 who were followed for four years found those who became pregnant were only marginally more likely to have followed recommendations on smoking, alcohol consumption and folic acid intake than their non-pregnant peers.

More than three-quarters of the 238 women who became pregnant had planned their pregnancy
to some degree but there was little difference between their lifestyle and that of the women who had not planned to conceive.

Professor Hazel Inskip, an epidemiologist at the Medical Research Council Centre in the University of Southampton and lead author of the study published in the British Medical Journal, said: "The foetus is particularly vulnerable in the first few weeks.

Early influences affect the risk of miscarriage, may contribute to the obesity epidemic, have an impact on IQ and all sorts of subtle long-term effects.

"How we protect the next generation is very important. Parents want the best for their children but people get more twitchy once their children are alive. Society needs to be thinking about this earlier."
Women trying to become pregnant should avoid tobacco and alcohol

The National Institute for Clinical Excellence (Nice) recommends that women trying to become pregnant should avoid tobacco and alcohol, take daily folic acid supplements to prevent birth defects, eat a healthy diet and take exercise, the scientists said, but few do so.

The results showed that less than three per cent of women who became pregnant complied fully with the guidance on alcohol and folic acid. But when they knew they were pregnant they followed the advice more closely.

Professor Inskip said: "The difficulty is that few women know when they are going to get pregnant. If your lifestyle is to go out drinking with friends you might not want to tell them. No one wants to say they are trying for a baby because it is so difficult if they fail."

Public health specialists at the University of Southern Denmark said: "Pregnancy has been called a window of opportunity for health promotion because it is thought to be the time when women are most willing to give up unhealthy habits... Sadly, the window often opens too late."

What to do

  • Follow a healthy, balanced diet with plenty of fruit and veg, starchy foods, and dairy. Avoid processed food and keep to two cups of coffee a day.

  • Cut out alcohol, smoking and drugs, which can affect the chances of conception and harm the foetus.

  • Wait three months after coming off the Pill before trying to conceive, to reduce miscarriage risk.

  • Take a multivitamin with 400 micrograms of folic acid every day for a month before trying to conceive

  • Make sure multivitamin supplements include zinc (30mg per day), selenium (100mg per day), iron and vitamins A, B, C and E.

  • Consider a general health check, especially if there is a family history of medical conditions such as diabetes, cystic fibrosis or epilepsy.

  • Take regular, moderate exercise.

  • Check vaccinations are up to date.



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    Octuplets' granny hits out at their mom

    Los Angeles - The mother of a woman who gave birth to octuplets Monday criticized her daughter's decision to have all eight children as "unconscionable" and questioned whether she could properly care for them.

    In an interview posted on the radaronline.com website and broadcast on US television, Angela Suleman said she was "very upset" after learning her daughter Nadya had implanted multiple embryos despite already having six children.

    Suleman, 33, gave birth to octuplets on January 26 in a case which triggered criticism from experts and an investigation by the California Medical Board.

    Suleman's mother, a retired teacher, said although she would do everything she could to care for her grandchildren, she was unhappy that her daughter had undergone in vitro fertilization to add to her brood.

    "To have them all is unconscionable to me. She really, really has no idea what she's doing to her children and to me," she said.

    "How she's going to cope, I don't know," Angela Suleman said. "I'm really tired of taking care of the six children and need her to think about how she'll provide for all these children."

    Angela Suleman said her unemployed daughter hadn't worked since she became a mother and that the three-bedroom home they shared was already close to being overwhelmed, even though the octuplets remain in hospital.

    "I'm struggling to look after her six," she said. "We had to put in bunk beds, feed them in shifts and there's children's clothing piled all over the house."

    The grandmother also took issue with her daughter's suggestion that she had wanted a huge family because of an unhappy childhood.

    "We raised her in a loving family and her father always spoiled her," Angela Suleman said.

    A spokesperson for Nadya Suleman, Michael Furtney, said his client declined to respond directly to her mothers comments. "She's going to keep her own counsel at this time," Furtney told AFP.

    The spokesperson did however take issue with Radar's depiction of the Suleman home as being in disarray, saying his client could not be held responsible. "Nadya hasn't lived in the house for two months," he said.

    The Medical Board of California said Friday it was probing the octuplets birth "to see if we can substantiate a violation of the standard of care."

    Under guidelines issued by the American Society of Reproductive Medicine (ASRM), a woman Suleman's age should have no more than two embryos implanted.

    Experts say multiple-birth babies are often born prematurely - Suleman's octuplets were born nine-and-a-half weeks early - which puts them at significantly greater risk of long-term health problems.

    Suleman last week defended her decision to have all eight children in an interview with NBC News, saying "all I wanted was children."

    "That's all I ever wanted in my life. Sometimes when we have that dream and that passion, we take risks. And I did. And it turned out perfectly," she said. - AFP



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    IVF: Where do you draw the line?

    New York - A lot of statistics came with the story of the young Californian mother who gave birth to a spectacular litter last week.

    The first was the number of babies involved: a magnificent eight.

    Seven was the number she had been told to expect.

    We learnt early on that 46 doctors and nurses were on the delivery team - it made you wonder whether there was room for the father to witness the miracle.

    By Sunday, we finally had the identity of the woman, Nadya Suleman, 33 (although ABC News was calling her Nadya Doud), along with a few other numbers.

    America no longer knew whether to praise this feat of fecundity - it is only the second time anyone in the US has borne eight babies, with every one surviving - or condemn it.

    These are times of parsimony, after all.

    Estimated cost of nappies for eight over a calendar year? $7 000 (about R71 645).

    Fathers present at birth or waiting at home? Zero.

    Reported income of mother? Possibly zero also.

    Then on Friday came the most disturbing figure of all: six. That is the number of children, aged two to seven, the woman already has - all through in vitro fertilisation.

    Angela, the children's grandmother, said her daughter had always been nuts about children and had sought fertility treatment because "her Fallopian tubes are plugged up".

    Things then went a bit out of control, she acknowledged.

    "Octuplets. Dear God! I wish she could have been a kindergarten teacher."

    The question is how Nadya managed to have so many embryos implanted.

    Was it true, as some reported, that she worked in a fertility clinic?

    For a few news cycles at least, the joy of the nation seemed unalloyed. Reality television is so contrived these days; real reality is always more gripping. And this is a show that could run and run.

    It is fair to assume that a producer somewhere is already trying to sign Nadya Suleman up for a multi-year deal.

    We are not acquainted with these babies yet, but we will be. In all likelihood we will watch them grow up - if Nadya co-operates.

    And there is money at stake. Ask Jon and Kate Gosselin, the parents of twins and sextuplets,
    who have their own show on the TLC Network, Jon and Kate Plus Eight.

    In return for publicity on the show, they get freebies all the time. Heavens, Kate has recently had a free tummy tuck.

    The risk for Nadya, however, is that the country may already be changing its stance on her.

    She will be watched on TV only if her story remains a miracle, not a mistake, and America is split down the middle on this one.

    With each passing press conference, the doctors at the Kaiser Permanente hospital in Bellflower who performed the deliveries become less puffed and more defensive.

    They wanted us to know that the mother had come to them after she had become pregnant. And yes, with eight foetuses she had undergone fertility treatment.

    And yes, they had suggested she selectively terminate at least some of them.

    That Ms Suleman eschewed all such options means that, among those opposed to abortion, she will always have a constituency who considers her heroic.

    Having more babies is always more good. That, however, is definitely not the view being expressed this weekend by most fertility experts in the US.

    Multiple births are "presented on TV shows as a 'Brady Bunch moment'," said Arthur Caplan, bioethics chairman at the University of Pennsylvania, referring to the seventies TV series. "They're not."

    He and others in the fertility profession were on Sunday worrying about a backlash thanks to the Suleman case that could lead to regulations governing the number of babies clinics could allow mothers to bear. Mr Caplan believes the physician who looked after Ms Suleman went far beyond the bounds of reasonable practice.

    "Anyone who transfers eight embryos should be arrested for malpractice," he said.

    But back to the mother. She, it seems, has been divorced since January last year, though her former husband is not the father of the six children she already has.

    She recently finished her studies in, appropriately, child development, and lives with her mother, who is herself divorced and recently overcame personal bankruptcy.

    Her ex-husband works in Iraq and still supports the family.

    When she sought treatment, in other words, Nadya was rich in offspring already but not in worldly goods. She and her family are not on welfare.

    However, the hospital bill for delivering and caring for the eight babies, born nine weeks prematurely and delivered by Caesarian section, could reach $1m.

    This is why insurance premiums keep going up for the rest of America.

    Babies born so early with so many siblings usually have continuing medical and psychological problems, which means more money.

    Janet and Graham Walton from Wallasey, Merseyside, had the world's first all-female sextuplets.

    The girls, conceived after 13 rounds of fertility treatment, were born healthy at 31 weeks in November 1983 and spent less than two months in hospital.

    Five of the girls, now 25, still live with their parents. Hannah is going to be a teacher; Kate works in IT; Sarah works in a health centre, and Ruth works at Manchester airport. Jenny, the sixth, is in cabaret in Majorca.

    Mr Walton said: "If they all left tomorrow, I wouldn't know what to do with myself without the noise. I love the buzz of a big family. We would be totally lost without them." - Independent on Sunday


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    Octuplets in incubators 'doing well'

    Bellflower, California - The nation's second set of live-born octuplets were all breathing on their own Wednesday, 48 hours after a woman gave birth to the surprising bunch in Southern California.

    Three of the babies were still receiving supplemental oxygen, but were inhaling and exhaling on their own.

    "They're doing amazingly well," said Socorro Serrano, spokesperson for Kaiser Permanente's Bellflower Medical Centre, where the babies were born.

    The mother, whose identity remains a secret, had not yet been able to hold any of the delicate babies - six boys and two girls - who were born weighing between 0,45kg, and 1,47kg). However, she was able to see them in their incubators on Tuesday night.

    In lieu of names, the babies have been assigned letters A through H, in the order of their birth Monday morning. The babies' incubators were being kept near one another in the same room for bonding, said Miriam Khoury, clinical director of inpatient obstetrical nursing at the hospital.

    Four of the babies were receiving tube-feedings of donated breast milk, said Khoury.

    The stomach of a fifth baby didn't absorb the milk he was given Wednesday and now was being fed intravenously, said Khoury. Two of the babies that were receiving milk also were being fed through a vein.

    The mother has begun pumping breast milk in anticipation of eight hungry babies, said Serrano.

    Five of the babies have begun feedings on donated breast milk through tubes. The three others were expected to begin feeding later on Wednesday.

    The mother has begun pumping breast milk in anticipation of eight hungry babies, said Serrano.

    Doctors were surprised by the birth of the eighth baby, because they were only anticipating seven, said Dr Harold Henry, one of 46 staff members who delivered the babies by cesarean section.

    Khoury said the addition of eight babies to the neonatal unit had not stressed the hospital.

    "This is history for us, so of course we're happy," said Khoury, who helped coordinate the materials needed for the labour.

    Details about how the octuplets were conceived have not been released, but doctors not involved in the delivery believe the mother was likely on fertility treatment.

    Dr Daniel Mishell, professor of obstetrics and gynaecology at the University of Southern California's Keck School of Medicine, recommends carefully monitoring pregnancies involving fertility drugs by ultrasound.

    Multiple births can be dangerous for babies and their mother, and in some cases, may result in lasting health problems. However, in cases where a woman insists on having multiple births, there's a limit to a doctor's role.

    The babies were expected to remain in hospital for several weeks and could face serious developmental delays because of their small size.

    On Wednesday, the father of the world's first set of octuplets born alive offered the nation's newest eight-sibling family a preview of what they have to look forward to.

    "Most of the time, (it's) really, really loud, because eight people are talking, wanting to be heard," Iyke Louis Udobi said as he looked over the two boys and five girls who were born to his wife in 1998 along with an eighth child, who died a week later.

    The children's mother, Nkem Chukwu, who breast-fed her infants a decade ago, has her own advice to offer the new mother.

    She should "take it easy," Chukwu said. "Pray more. ... Sleep while she can." - Sapa-AP


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    New 'test tube' technique offers hope

    London - A British team has for the first time successfully used a new "test tube" fertilisation technique that better predicts which of a woman's eggs will most likely result in pregnancy, a top fertility expert said on Monday.

    The treatment combines currently used prenatal screening with a new computer program that can scan the eggs for flaws in chromosomes that may lead to miscarriage.

    The first patient, a 41-year-old British woman who failed 13 rounds of fertility treatment, is now pregnant, the researchers said.

    The ultimate goal is more pregnancies and fewer multiple births and miscarriages, added Simon Fishel, managing director of CAREfertility, the clinic that developed the technique.

    "We are going to go slowly with the technology because we don't want to raise hopes," Fishel told a news conference. "The Holy Grail is to achieve one pregnancy with one embryo."

    More than 3,5 million babies have been born worldwide using assisted reproductive technology since July 25, 1978, when two British doctors delivered the world's first test-tube baby, Louise Brown.

    That number is growing faster because more women are waiting longer to start having children, and cheaper air travel makes it possible for even more couples to seek in-vitro fertilisation or IVF. Most treatments are in women aged between 30 and 39.

    The technique involves surgically removing eggs from a woman's ovaries and combining them with sperm in the lab. Doctors then pick the best embryos - typically one or two - and implant them in the woman's uterus.

    The challenge is choosing the best embryo, said Fishel, who was part of the team that delivered Brown.

    Currently, doctors often use a microscope to pick the best shaped embryos, instead of checking the DNA, Fishel said.

    "We can now look at all the chromosomes in an embryo in real time so we can put forward a fresh embryo after looking at its chromosomes," he said.

    Fishel's team, which refined a complex technique to detect chromosomal problems, took a sample of the tiny part of an egg called the polar body that contains half the egg's chromosomes but does not take part in the fertilisation process.

    They used a new computer programme to find that two of nine eggs from the woman who had failed IVF treatment 13 times were promising candidates.

    The woman, who wishes to remain anonymous, is now entering her final two months of pregnancy.

    "Although it is still at a very early stage, this technique may offer a new diagnostic and therapeutic hope to couples who suffer from repeated implantation failure in IVF," said Stuart Lavery, IVF director at Hammersmith Hospital in London.


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    The dangers of being an older dad

    Women with older partners may be at higher risk of suffering miscarriages irrespective of their own age, according to a study that has linked the increased chance of a failed pregnancy with men over the age of 40.

    Until now it was widely assumed that miscarriage rates largely increased with female age only, but a study into women undergoing artificial insemination with their partner's sperm has found that it can also be linked with older men. Scientists also found that pregnancy rates fell as the male partner gets older. This may reflect a decline in sperm quality in men over 40 that affects both the chances of conception and the increased risk of a miscarriage, they said.

    It is the first time scientists have discovered such a strong paternal effect on rates of pregnancy and miscarriage, and they suggest that, in future, fertility clinics should look more closely at the age of men as well as the age of women when advising on treatment.

    Stephanie Belloc, of the Eylau Centre for Assisted Reproduction in Paris, said: "Until now … the message was to get pregnant before the age of 35 or 38 because afterwards it would be difficult. But now the gynaecologists must also focus on paternal age and give this information to the couple.

    'Fertility clinics should look more closely at the age of men'
    "We suggest that there is a link between paternal age and DNA decay in the spermatozoa because we previously demonstrated that age is associated with increased sperm DNA fragmentation. So maybe there is a link between paternal age and DNA decay that are implied in the miscarriages.

    "I think it's important to consider not only the woman, but both members of the couple in natural conception, but also in assisted reproductive technology [such as artificial insemination and IVF]."

    The scientists analysed data gathered at a fertility clinic that performs artificial inseminations directly into a woman's uterus, a technique which improves the conception rate.

    They followed up 21 239 cases of these intrauterine inseminations to see whether the age of the man or the woman had any significant effect on the chances of conception and miscarriage.

    As expected, they found maternal age was a strong factor in pregnancy rates, with just 8.9 percent of women over the age of 35 getting pregnant, compared with 14.5 percent in younger women.

    'We also found that the age of the father was important in pregnancy rates'
    "But we also found that the age of the father was important in pregnancy rates - men over 35 had a negative effect," said Belloc.

    "And, perhaps more surprisingly, miscarriage rates increased where the father was over 35."

    The study - the results of which were to be released this week at the European Society for Human Reproduction and Embryology in Barcelona - found the miscarriage rate among women with partners aged between 35 and 39 was 18.1 percent, but 33 percent for the partners of men aged between 40 and 44.

    Couples undergoing assisted reproductive technology where the man is older than 35 or 40 should consider using the technique of intracytoplasmic sperm injection (ICSI), for directly injecting single sperm into an egg, because then the best sperm could be chosen for fertilisation, Belloc said.

    "It's the conclusion of my study that ICSI should be the [technology] of choice when paternal age is increasing because we can choose the best spermatozoa.

    "We can choose spermatozoa without DNA fragmentation, and DNA fragmentation is increasing with paternal age. So it is a way to be free of paternal age."


    Older dads

  • TV presenter Des O'Connor's wife, the Australian singer-songwriter Jodie Brooke Wilson (35), gave birth to their son Adam in September 2004. O'Connor, then 72, claimed: "It felt like the right time."

  • US presidential hopeful John McCain was 48 when he and his wife Cindy had their first child together, the now-award-winning blogger Meghan McCain. They have since had two more.

  • There were a few sleepless nights at the Playboy mansion in the early 1990s when a sexagenarian Hugh Heffner fathered sons Marston and Cooper by his fiancee Kimberley Conrad.

  • When Leo Blair was born in 2000, 47-year-old Tony became the first serving prime minister to have a baby in more than 150 years.

  • Actor David Jason became a dad for the first time aged 61 when his daughter, Sophie Mae, was born.

  • A 56-year-old Michael Douglas welcomed Dylan Michel into the world in 2000, then married the mother, Catherine Zeta-Jones, soon afterwards. The couple had a daughter three years later. - The Independent

    • This article was originally published on page 16 of The Star on July 26, 2008


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    Big support for Philippines family planning

    Manila - More than 80 percent of Filipinos support family planning and almost half believe the government should limit the number of children a couple can have, according to a survey released here on Monday.

    The findings come despite a widespread campaign by the dominant Roman Catholic Church opposing a draft law that would make family planning services more widely available in the Philippines.

    The survey of 1 200 adults conducted in late-October found that 82 percent believed that the government had a "duty" to provide information, services and materials on artificial contraception, said the Pulse Asia research group.

    The survey also found that 44 percent believed that "the government should pass a law specifying the number of children."

    The survey, which has a margin of error of three percent, did not ask them what the limit should be.

    Additionally, 93 percent of those surveyed said that family planning was important both for families and the country.

    Sixty-three percent of Filipinos also said they were in favour of the controversial bill promoting information and use of contraceptives, despite the Church's opposition.

    The Catholic Church, which counts over 80 percent of Filipinos as followers, has said the reproductive health bill, which has been pending in Congress for months, is headed for defeat after a high-pressure campaign by bishops.

    The Philippine population now stands at around 90 million, with an annual growth rate of 2,04 percent, one of the highest in Asia and above the government's target of 1,9 percent, officials have warned.


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    First 'genetically screened' girl born

    London - The first baby girl in Britain to have been screened before conception for a genetic form of breast cancer has been born, doctors said on Friday.

    Doctors at University College Hospital in London had created a number of embryos through in vitro fertilisation for the baby's parents and screened them for the variant BRCA1 gene.

    Women who carry this genetic variation have an 80 percent chance of developing breast cancer and a 60 percent chance of suffering ovarian cancer during their lifetime and the couple's children were at very high risk of inheriting the gene.

    However, carrying the gene does not make cancer inevitable.

    'The lasting legacy is the eradication of this form of cancer'
    "This little girl will not face the spectre of developing this genetic form of breast cancer or ovarian cancer in her adult life," said Paul Serhal, Medical Director of the Assisted Conception Unit at the hospital.

    "The parents have been spared the risk of inflicting this disease on their daughter. The lasting legacy is the eradication of the transmission of this form of cancer that has blighted these families for generations."

    The mother and baby girl, who have not been identified, are doing very well.

    The embryo was chosen using pre-implantation genetic diagnosis, which involves testing cells to see if they contain the faulty gene. An embryo found not have the gene was then implanted into the mother.

    The Human Fertilisation and Embryology Authority, which had to approve the procedure, said the chosen embryo had not been genetically manipulated or programmed.

    While a first in Britain, pre-implantation genetic diagnosis has been used elsewhere across the world to screen for the variant BRCA1 gene and the technique has also been previously applied by British doctors to avoid the transmission of other cancers and diseases. - Reuters




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    Leaner men have better sperm - study

    New York - Obese men are more than three times as likely to have low sperm counts compared with their normal-weight peers, a study out this month in the journal Fertility and Sterility shows.

    The heaviest men were also at triple the risk of having a low count of progressively motile sperm - sperm that swim forward in a straight line, Dr Ahmad O. Hammoud of the University of Utah in Salt Lake City and colleagues found.

    "There is a strong relationship between overweight and obesity and altered sperm parameters," Hammoud and his team write. Future studies should look at this relationship over time, they say, as well as how weight loss might affect sperm characteristics.

    There has been some evidence that obesity may impair fertility in men, the researchers note, while increased body fat can contribute to lower testosterone levels and higher oestrogen levels. To examine how body mass index (BMI) affects sperm quality, they evaluated 390 men who sought infertility treatment with their partners over a two-year period.

    Twenty-four percent of the men were normal weight, 43 percent were overweight, and 33 percent were obese. Overall, 10.5 percent had low sperm counts.

    The prevalence of low sperm counts rose as BMI increased; obese men were 3.3 times more likely to have low sperm counts than normal-weight men. The risk of having a low count of progressively mobile sperm also rose with BMI; obese men were 3.4 times more likely than normal-weight men to have a low progressively mobile sperm count. Obese men were also 1.6 times more likely than overweight or normal-weight men to have a high percentage of abnormally shaped sperm.

    While there was a trend toward increasing likelihood of erectile dysfunction with increasing BMI, the relationship wasn't statistically significant. However, the researchers note, other studies have found that obesity is associated with a greater risk of impotence.

    The fact that the study was done among men seeking infertility treatment makes it likely that the study group had worse sperm quality than the population at large, Hammoud and colleagues point out. Nevertheless, they add, the correlation of poor sperm quality and increased BMI in the general population is probably similar. - Reuters


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    Teens don't know risk factors of infertility

    Canadian high school students may lack important knowledge about risk factors for infertility, survey findings suggest. For example, most students were unaware that some sexually transmitted infections can cause infertility.

    "About 80 percent of students said they were familiar with the term infertility," Susan Quach, of Sunnybrook and Women's College Hospital Fertility Centre in Toronto, told Reuters Health. But when asked more specific infertility-related questions, fewer students answered correctly, indicating a lack of knowledge that may increase their risk of infertility later in life, Quash said.

    For example, more than 94 percent of the students did not know that sexually transmitted infections, such as chlamydia or gonorrhoea can lead to infertility, Quash and co-investigator Dr. Clifford Librach at the University of Toronto report in the journal Fertility and Sterility.

    The researchers asked 772 ethnically diverse high school students to complete a written questionnaire designed to determine their knowledge of and attitudes about infertility. The students were 17,5 years old, on average, and 49 percent were female.

    A total of 608 students completed the questionnaire and, as noted, the vast majority did not know that chlamydia and gonorrhoea can lead to infertility. About 25 percent thought fertility problems only occurred among women 40 years or older.

    The researchers found that students from schools with low socioeconomic status more frequently gave incorrect answers and were significantly less aware of associations between sexually transmitted diseases and infertility.

    Overall, about 73 percent of female and 67 percent of male respondents said protecting their fertility was important to them. Most also reported that their fertility was important to them. Fifty-five percent of the students said they were open to screening for sexually transmitted diseases as a means of protecting their fertility.

    These findings highlight the importance of educating young people about modifiable risk factors for infertility, such as body fat, smoking, caffeine consumption, excessive exercise, drug use, and sexually transmitted infections, Quash and Librach note.

    To assist the development of targeted and appropriate infertility prevention education, the investigators suggest that further infertility knowledge assessments should be conducted among students in rural or less ethnically diverse schools.



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    Second-hand smoke tied to fertility problems

    Women who have ever been around smokers regularly may have more difficulty getting pregnant than those who have not, a new study suggests. The findings, researchers say, offer one more reason for women to kick the smoking habit.

    Studies have found that women who smoke raise their risk of a number of pregnancy complications, as well as their infants' risk of health problems. Less is known about the dangers of second-hand smoke, though some studies have linked exposure during pregnancy to an elevated risk of miscarriage.

    In the new study, of more than 4 800 women, researchers found those who'd grown up with a parent who smoked were more likely to report they'd had difficulty becoming pregnant - defined as having to try for more than one year.

    In addition, women who'd been exposed to second-hand smoke in both childhood and adulthood were 39 percent more likely to have suffered a miscarriage or stillbirth, and 68 percent more likely to have had problems getting pregnant.

    "These statistics are breathtaking and certainly (point) to yet another danger of second-hand smoke exposure," said lead researcher Luke J. Peppone at the University of Rochester, New York.

    "We all know that cigarettes and second hand smoke are dangerous," he added. "Breathing the smoke has lasting effects, especially for women when they're ready for children."

    Peppone and his colleagues at the University of Rochester in New York report their findings in the December 5 online issue of the journal Tobacco Control.

    For the study, the researchers analysed surveys from 4 804 women who'd visited the university's Roswell Park Cancer Institute between 1982 and 1998 for health screening or cancer treatment. All had been pregnant at least once in their lives.

    Overall, Peppone's team found 11 percent of the women had difficulty becoming pregnant, while one third had a miscarriage or stillbirth.

    The risk of these problems tended to climb in tandem with the number of hours per day that a woman was exposed to second-hand smoke - a pattern that suggests a cause-effect relationship.

    Second-hand smoke contains a host of toxic compounds that could potentially harm a woman's reproductive health, Peppone and his colleagues note. Tobacco toxins may damage cells' genetic material, interfere with conception, raise the risk of miscarriage, or inhibit the hormones needed for conception and a successful pregnancy.


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    Ladies, fizzy drinks will not kill sperm...

    Paris - The belief that Coca-Cola works as an after-sex spermicide is nothing but an urban legend, a scientist cautions in the British Medical Journal (BMJ) on Thursday.

    Deborah Anderson, a professor in obstetrics and gynaecology at Harvard Medical School, says that Coca-Cola douches were sometimes used in 1950s and 1960s America in the belief that the drink's acidity killed sperm.

    Soft-drink douches are still used as a post-coital contraceptive ploy in some poor countries, she says.

    But, says Anderson, there is no evidence to suggest these unusual forms of contraception work - and plenty of reasons to suggest they could cause harm.

    To begin with, Coca-Cola is not a very effective spermicide, as it is unlikely to kill the target.

    And even if the beverage's secret recipe were lethal, a speedy sperm is likely to outswim the douche and get to cervix first.

    In addition, Coca-Cola damages the top layer of cells within the vagina, and makes a woman more prone to sexually transmitted disease. And while it is largely harmless to sperm, Coca-Cola removes healthy bacteria, opening the way to fungal and bacterial infection.

    Experiments with other forms of vaginal douches have found an increased risk of pelvic inflammation and ectopic pregnancy, in which a fertilised egg is implanted in the fallopian tube, rather than in the uterus.

    Finally, says Anderson, there is the simple fact that there are much more effective and easy-to-use methods of contraception widely available.

    Anderson also said there was a reason why she had gone into print.

    An old study by her research group, on the impact of Coca-Cola on human semen, had recently been resurrected and had won a spoof Nobel prize, or IgNobel, for offbeat science.

    She was afraid that the headlines surrounding this award may have repopularised the legend. - AFP


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    Baby girl born from full ovary transplant

    Doctors in St. Louis in the US say they have successfully transplanted a full ovary from a volunteer, allowing her infertile twin sister to give birth to a healthy baby girl on November 11.

    It is the first time an entire ovary has been transplanted and resulted in a live birth, the researchers said. Writing in the New England Journal of Medicine, they said the method may offer a way to preserve fertility for cancer patients or for women who want to wait until they are older to start families.

    One twin went into early menopause at age 15, but the transplanted ovary from her sister restored full fertility and she gave birth at the age of 38, Dr. Sherman Silber of the Infertility Centre of St. Louis and his colleagues reported.

    Previously they had transplanted the outer shell of the ovary and found that, even if the tissue is frozen, it can restore fertility.

    Although six babies were born to eight women using those techniques, about two-thirds of the eggs die from lack of blood flowing through the tissue, and the women quickly slip into menopause after about three years.

    Hoping to avoid those problems, the Silber team used a full ovary and reconnected two veins and one artery to feed the graft, which is a challenge because the blood vessels are so tiny.

    Silber said although the work has involved identical twins where one had become prematurely infertile, the technique could eventually benefit two groups of women if frozen ovaries turn out to be as viable.

    "One is the young cancer patient who is about to lose all her ovarian function as she's about to undergo chemotherapy. We just take that ovary out, freeze it and transplant it back. That's one big payoff," he said.

    The other, he acknowledged, is more controversial: extending the time a woman is fertile.

    Women in their 20s could have one of their two ovaries removed so it can be frozen. "If she's 40 or 45 when she has it transplanted back, it's still a 25- or 30-year-old ovary, so she's preserving her fertility," he said. "We've actually done it for quite a few patients. I think there will be many more women who will want to do that."

    The infertility rate at age 25 is only about six percent. It jumps to 70 percent by age 40 and is about 95 percent at age 43, said Silber.


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    Girls, go for the smart guys

    The smarter the man, the higher the quality of his sperm, new research published in the journal Intelligence shows.

    But women having difficulty conceiving shouldn't question their partner's intelligence and men who aren't quite geniuses should not worry about their ability to father children, lead researcher Rosalind Arden of Kings College London told Reuters Health. "This is scientifically interesting, but unimportant in terms of people's likelihood of conception or fertility," she said.

    Scientists have wondered whether there might be a human "fitness factor," a correlation between several characteristics of the mind and body that could help determine a person's likelihood of passing on their genes to future generations. Candidate characteristics include intelligence, height, attractiveness, resistance to disease, and mental stability.

    Several studies have shown that taller people tend to be smarter, providing some support to this idea.

    Arden and her colleagues set out to see if sperm quality and intelligence might be similarly related. "We were particularly interested in sperm quality because sperm quality seems to be such a commonsense measure of what evolutionary people call fitness, which means the likelihood of surviving and having children," she explained.

    They looked at a sample of 425 Vietnam era veterans who underwent intelligence testing and sperm quality measurements between the ages of 31 and 44. The researchers calculated intelligence by incorporating the men's results on five different tests. They then compared this "intelligence factor" to the men's sperm concentration, sperm count and sperm motility.

    Intelligence rose in tandem with each of the three measures of sperm quality, the researchers found. The relationship remained statistically significant even after accounting for the potential effects of age, cigarette smoking, body mass index, alcohol consumption and sexual abstinence.

    The size of the relationship between sperm quality and intelligence was similar to that previously observed between height and intelligence, Arden said, although it may be even larger given that height is more reliably measured than sperm quality.

    The idea of a "fitness factor" should not be interpreted to mean that only the genes of the very handsomest, smartest, and tallest will be passed along, according to Arden.

    "Throughout history, as far as we know it, most men and women have ended up having some children," she noted. "It's the people who are at least average and a little bit above average who tend to have more children.

    "It's not necessarily that women are going to favour men who are going to be rocket scientists, fantastically intelligent, fantastically cool," Arden added. "They might just say, 'I'd rather not have the guy who has a whole suite of unpleasant characteristics, I'd rather have the guy who is at least average."


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    IVF less successful in black women

    African-American women who undergo in vitro fertilisation (IVF) are less likely to ultimately have a baby than are their white counterparts, a new US study suggests.

    Using data for more than 70 000 IVF treatment cycles performed nationally, researchers found that black women who underwent IVF using their own unfrozen eggs were less likely to become pregnant and more likely to miscarry than white women having the same procedure.

    The birth rate per treatment cycle was about 19 percent among black women, versus 26 percent among white women.

    There was, however, no racial disparity among women who underwent IVF using frozen embryos, with birth rates of 16 percent for white women and 16,5 percent for black women.

    The researchers, led by Dr. David B. Seifer of Maimonides Medical Centre in Brooklyn, New York, report the findings in the journal Fertility and Sterility.

    Some previous studies examined the racial differences in IVF success rates, but have come to conflicting conclusions. To try to resolve the question, Seifer's team used data from a federal registry that collects information from fertility clinics nationwide; the researchers focused on 72 273 IVF treatment cycles performed between 1999 and 2000.

    The majority were performed in white women, with African-American women accounting for about 3 700 of the treatment cycles.

    The reasons for the lower success rate among black women are not clear, but the data suggest some possibilities, according to Seifer and his colleagues.

    Black women, they note, tended to have more abnormalities of the pelvic structures, which can lower the likelihood of pregnancy and increase the risk of miscarriage.

    Black women also tended to be older when they first sought IVF treatment and had fertility problems for a longer time - two more factors that dim the chances of success.

    More studies are needed to understand why racial disparities in IVF success exist, according to the researchers. This is especially important, they note, in light of recent research showing that while infertility is becoming less common among white US women, it is on the rise among African Americans.


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    Fertility declines with shorter cycles

    As a woman's menstrual cycle shortens with advancing age, her odds of becoming pregnant decreases, Swedish investigators report in the journal Fertility and Sterility.

    Dr. Thomas Brodin of Malarsjukhuset in Eskilstuna, Sweden, and colleagues analysed successful pregnancy and delivery rates in 6 271 in vitro fertilisation cycles in terms of menstrual cycle length. Their objective was to determine if cycle length could be used as a marker for fertility potential.

    "Increasing age was associated with a subtle shortening of (average) menstrual cycle length. The (average) shortening of menstrual cycle length is about two days from the twenties to the forties," Brodin said in an interview with Reuters Health.

    After accounting for age, the menstrual cycle length was directly related to the odds of pregnancy and delivery, the team found. "The chance of delivery after (in vitro fertilisation) was almost doubled for women with a menstrual cycle length longer than 34 days compared with women with a menstrual cycle length shorter than 26 days."


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    Women unaware of risks of delayed motherhood

    Many women may not be fully aware of the potential consequences of waiting until later in life to have a baby, a UK study suggests.

    The study, of 724 women who were either pregnant or having trouble getting pregnant, found that nearly all were aware that age affects the chances of conceiving. However, they often did not know that older age increases the risk of certain pregnancy complications, and many had too much faith in the success of in-vitro fertilisation (IVF).

    The decision to delay childbirth is a complex and personal one, the researchers note in a report in the journal Fertility & Sterility.

    The point, they say, is that women should be fully aware of all the possible benefits and risks of their decision.

    "The results of this and other studies suggest that women should be provided with the appropriate information on the possible outcomes of a decision to delay motherhood," write Dr. Abha Maheshwari and colleagues at the University of Aberdeen in England.

    They analysed questionnaire responses from 362 women getting prenatal care and 362 women seeking fertility counselling at the university medical centre. The researchers found that 85 percent of women with fertility problems and 76 percent of pregnant women were aware that fertility declines between the ages of 30 and 40.

    Most women in both groups were also aware that pregnancy complications become more common with age. Still, fewer than half in each group knew that age increases the risk of pregnancy-related diabetes and the need for a cesarean section. Only about one-fifth of each group knew that age boosts the chances of having twins.

    When it came to IVF, Maheshwari's team found that women tended to be overly optimistic about its success rates.

    Only 53 percent of women with fertility problems knew that the chances of conceiving via IVF decline between the ages of 30 and 40. What's more, 85 percent of them thought that fertility treatment can "overcome the effect of age."

    In reality, the researchers note, only 25 percent to 30 percent of women in their 20s and 30s give birth after IVF treatment. Among women older than 40, the success rate is closer to 10 percent.

    Yet many people may not realise that IVF frequently fails, Maheshwari's team writes - possibly because much of what they hear about IVF comes in the form of media stories on older women who have successfully conceived through fertility treatment.

    "Many women are currently choosing to delay motherhood in the interests of personal and professional development," the researchers write. "Although starting a family is a personal preference, free choices cannot be made without full knowledge of their consequences."


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    Placebo acupuncture works better for IVF moms

    A study in Hong Kong has found that placebo c led to significantly more pregnancies among women who underwent in-vitro fertilisation (IVF) than those who received real acupuncture.

    In the trial, the researchers used a placebo needle that looked identical to a real acupuncture needle, but which was blunt and retracted into the handle of the needle when pressed on the skin, while still giving the appearance and sensation of entering the skin.

    In an article published in Human Reproduction, the researchers said a trained acupuncturist applied the placebo to the same acupuncture points as those for real acupuncture.

    Half of the 370 women were given real acupuncture and the other half placebo acupuncture twice - 25 minutes before and 25 minutes after embryo transfer.

    Ernest Ng, associate professor in obstetrics and gynaecology at the University of Hong Kong, said the overall pregnancy rate for placebo acupuncture was 55,1 percent, compared to 43,8 percent for real acupuncture.

    Ng offered two possible reasons for the results.

    "Placebo acupuncture is similar to acupressure and therefore is good enough to improve the pregnancy rate. Or else, it's possible that real acupuncture may, in some way, reduce the pregnancy rate of acupuncture," he said in a statement.

    However, he noted that there was no evidence for the latter hypothesis as past studies found higher pregnancy rates in the acupuncture groups than those receiving no acupuncture at all.

    The researchers thought it was more likely that this form of placebo acupuncture may actually have a real effect because levels of patient stress changed significantly whether the women received real or placebo acupuncture.

    Ng urged for more studies comparing placebo or non-invasive acupuncture and controls without acupuncture.



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